How much does palbociclib/palbociclib cost after medical insurance reimbursement

The original drug Palbociclib has been launched in my country and has been included in the medical insurance system, but only patients who meet specific indications can enjoy medical insurance reimbursement. Common drug specifications in the domestic market include 75mg 21 tablets, 100mg 21 tablets and 125mg 21 tablets. Their selling prices remain at about RMB 5,000. Due to different reimbursement ratios in different regions, the price after reimbursement will vary.

Palbociclib is an oral targeted drug approved by the U.S. Food and Drug Administration (FDA) for the treatment of breast cancer. It belongs to a class of drugs called CDK4/6 inhibitors, which are widely used in breast cancer patients. Breast cancer is one of the most common malignancies in women, and in many cases, breast cancer cells are hormone-dependent. Palbociclib prevents the proliferation and growth of cancer cells by inhibiting cyclin-dependent kinase 4 and kinase 6 (CDK4/6). It is often combined with other drugs, such as steroid estrogen receptor modulators (SERDs) or aromatase inhibitors (AIs), to increase its therapeutic effect.

In comparison, the price of the overseas version of the original drug of the same specifications is more than double. The price of 125mg 21 tablets may be as high as about 10,000 yuan (price is affected by exchange rate changes). In addition, there are also generic drugs in overseas markets. Although the manufacturers are different, their main ingredients are the same as the original drugs, but the price is significantly lower. For example, the price of medicines of the same specifications produced by Bangladeshi pharmaceutical factories is only about 900 yuan. Of course, this price will also fluctuate with exchange rate changes.