How much does a box of Crizotinib/Xalkori targeted drugs cost?

Crizotinib/Crizotinib (Crizotinib) is an ATP-competitive small molecule inhibitor of receptor tyrosine kinase (RTK) c-Met, anaplastic lymphoma kinase (ALK) and ROS1. Clinical evidence supports efficacy in non-small cell lung cancer (NSCLC) harboring EML4-ALK rearrangements that lead to constitutive activation of ALK-RTK. The drug is approved for this entity, which represents no more than 3-5% of non-small cell lung cancers. In some patients with NSCLC, the ALK gene is rearranged, resulting in overexpression of the ALK protein. Patients with ALK-rearranged lung cancer have a poor response to traditional chemotherapy methods, and crizotinib can specifically inhibit ALK kinase activity, thereby slowing tumor growth.

In addition to non-small cell lung cancer, crizotinib can also be used to treat other types of cancer, such asALK-positive lymphoma and ALK-mutated neuroblastoma. The drug can inhibit the proliferation and survival of tumor cells by binding to ALK kinase and blocking its signaling pathway. Crizotinib is usually taken as an oral medication. During the treatment process, the doctor will adjust the dosage according to the patient's specific situation and condition. However, like all medications, crizotinib may cause side effects such as nausea, vomiting, diarrhea, fatigue, etc.

The original drug of crizotinib has been launched in China and is included in the medical insurance. Its price is usually relatively high. The common ones are 250mg*60 capsules and 200mg*60 capsules. The price of each box may be more than 10,000 yuan. Currently, the original crizotinib drug sold overseas may cost more than RMB 10,000 per box of 250mg*60 tablets (the price may fluctuate due to exchange rates).

There are already cheaper generic crizotinib drugs overseas, and their drug ingredients are basically the same as those of the original drugs sold domestically and abroad. For example, the specifications produced by pharmaceutical factories in Bangladesh and LaosThe price of 250mg*60 tablets per box may be around 2,000 yuan (the price may fluctuate due to exchange rates).