Common side effects of crizotinib/Xalkori

Crizotinib/Crizotinib (Crizotinib) is a drug used to treat adult patients with ALK- or ROS1-positive non-small cell lung cancer. While it has shown significant efficacy in clinical studies, there are some common side effects.

One of the most common side effects is visual impairment, where patients may experience blurred or out-of-focus vision. In addition, nausea, diarrhea, and vomiting are also common adverse reactions, which may make patients feel sick and tired. Some patients may also experience symptoms of edema and constipation, which may cause some trouble in their daily lives. In addition to the above symptoms, crizotinib may cause elevated transaminases, indicating some degree of impairment of liver function. Some patients may experience fatigue and decreased appetite, which may affect their normal life and nutritional intake.

In addition, crizotinib may cause other adverse events. Some patients may experience symptoms such as upper respiratory tract infection, dizziness, and neuropathy. There are also reports that the drug may cause adverse events such as elevated blood creatine phosphokinase.

In the prescribing information for crizotinib, there are also several warnings and precautions listed. The first is the risk of liver toxicity, and patients need regular liver function monitoring while taking the drug. The second is the risk of interstitial lung disease or pneumonia. Patients should seek medical treatment promptly when they find symptoms such as difficulty breathing, coughing or chest pain. In addition, this drug may cause QT interval prolongation and bradycardia, requiring special attention to the patient's heart health. In addition, eye problems such as severe vision loss may also occur, and patients should pay close attention to their visual status while using this drug. Finally, for children and young adults with ALCL or children with IMT, this drug may cause gastrointestinal toxicity and needs to be used with caution.