Can cabozantinib/cazantinib be purchased in China? How much does a box cost?

Cabozantinib is already on the market in China and is covered by medical insurance. For patients who urgently need this drug, they can obtain it through formal and legal overseas channels. There are multiple original versions of cabozantinib, such as the Turkish version, the European version and the Japanese version, and their prices are relatively high, about 40,000 to 50,000 yuan.

In places such as India, Laos and Bangladesh, there are regular and legal generic drugs available. The main ingredients of these generic drugs are basically the same as the original version of cabozantinib, and the price ranges from a few hundred to several thousand yuan.

Cabozantinib is used to treat advanced kidney cancer and is also used to treat liver cancer after previously receiving sorafenib. Cabozantinib can also be used to treat thyroid cancer in people 12 years of age and older. Used to treat thyroid cancer that has spread to other parts of the body.

Cabozantinib has shown significant efficacy in the treatment of various cancers, but it may also cause some adverse effects. The most common adverse reactions include diarrhea, stomatitis, palmar-plantar erythrodysesthesia syndrome (PPES), weight loss, loss of appetite, nausea, fatigue, oral pain, hair color changes, dysgeusia, hypertension, abdominal pain and constipation. In addition, there are some common laboratory abnormalities, such as elevated AST and ALT, lymphopenia, etc.

When dealing with these adverse reactions, doctors will adjust the drug dosage, interrupt treatment, or provide corresponding supportive treatment according to the patient's specific situation. For example, for patients with mild diarrhea symptoms, antidiarrheal drugs and oral rehydration salts can be given for symptomatic treatment; if the diarrhea is severe or dehydration symptoms occur, intravenous fluid infusion is required to maintain water and electrolyte balance.