How much does a box of Seleniso (Silvio) cost?

Selinexor (Selinexor), trade name XPOVIO, is a new oral selective nuclear export inhibitor (SINE). It works by targeting the nuclear export protein XPO1 (also known as Exportin 1), XPO1 an important mediator of the transport of a variety of proteins and RNA between the nucleus and cytoplasm. Seliniso (Silvio)’s unique mechanism is to inhibit XPO1, which leads to the accumulation of tumor suppressor proteins in the nucleus, induces apoptosis, and inhibits the growth of cancer cells.

Seleniso (Silvio) is currently on the market in China and has been included in medical insurance. Patients can purchase it domestically, and the price is about more than 5,000 to 10,000 yuan. For specific prices and medical insurance reimbursement, please consult the local hospital pharmacy. The cheaper foreign generic drugs of Seleniso (Silvio) are mainly Lao version of generic drugs. The price is about more than 2,000 yuan, and the ingredients of the drugs are basically the same as those of the domestic original drugs.

Selinisol (Silvio) is mainly used to treat multiple myeloma and diffuse large B-cell lymphoma (DLBCL). In 2019, Seliniso (Sivio) was approved by the U.S. Food and Drug Administration (FDA) for the first time as a treatment option in combination with dexamethasone for patients with multiple myeloma who have experienced at least four different therapies and are still relapsed or refractory. In 2020, the FDA further approved it for the treatment of relapsed or refractory DLBCL patients.

Clinical studies have shown that Selinisol (Silvio) combined with dexamethasone has significant efficacy in the treatment of multiple myeloma. Data show that in patients with multiple myeloma, the objective response rate (ORR) of treatment with Seliniso (Silvio) plus dexamethasone is approximately 26%. In addition, Seliniso (Silvio)It has also shown potential efficacy against a variety of tumor types, including acute myeloid leukemia (AML), ovarian cancer, and pancreatic cancer.

Although selinesol (Silvio) has shown significant anticancer potential, its use is associated with some adverse effects. The most common adverse reactions include nausea, decreased appetite, fatigue, weight loss, thrombocytopenia, and hyponatremia. These side effects need to be closely monitored and managed during treatment.