Seleniso (Silvio) Medication Guide: Detailed explanation of correct usage and dosage

Selinisol (Silvio) , as an innovative oral drug, is a member of the selective nuclear export inhibitor (SINE) family and is widely used in multiple myeloma (MM) and treatment of relapsed/refractory diffuse largeBcell lymphoma (DLBCL). To ensure that patients can use this medication correctly and safely, this article will provide detailed medication guidelines.

1. Medication dosage and regimen

1.Combined bortezomib and dexamethasone for the treatment of multiple myeloma:

Selinisol (Silvio) : The recommended dose is 100 mg taken by mouth 1 time per week on the first day of each week. This treatment regimen should be continued until the disease progresses or the patient cannot tolerate the toxic effects of the drug.

Bortezomib: The dose is 1.3mg/m² administered by subcutaneous injection, also 1 times per week on the first day of each week. The drug needs to be used continuously for 4 weeks, followed by a break of 1 week.

Dexamethasone: 20mg each time, taken orally, 2 times a week, on the 1 day and the 2 day respectively.

2.Combined dexamethasone for the treatment of multiple myeloma:

Selinisol (Silvio) : Adjust dose to 80mg each time, taken orally, 2 times a week, specifically on the 1 day and the 3 day of the week. Continue medication until disease progression or toxicity becomes intolerable.

Dexamethasone: Synchronized with Selinexol (Silvio), 20 mg each time, orally, also on the 1 day and the 3 day of the week.

3.Treatment of relapsed/refractory diffuse largeB cell lymphoma (rrDLBCL):

Selinisol (Silvio) : The recommended dose is reduced to 60mg each time, taken orally, 2 times a week, on the 1 day and the 3 day of the week. Treatment is continued until disease progression or drug toxicity becomes intolerable.

2. Important tips for taking medicine

1.Timing: Patients must strictly follow the doctor's instructions and take the medicine at the specified time and day every week to ensure the stability of blood drug concentration.

2.Taking after meals: It is recommended to take the medicine within 1 to 2 hours after a meal, which will help reduce possible stomach discomfort.

3.Dose catch-up: If a dose is accidentally missed, it should be replenished as soon as possible, but avoid taking double doses on the same day.

4.Drug interactions: During the period of taking Seliniso (Sivio) , you should try to avoid using it at the same time with other drugs, or use it in combination under the guidance of a doctor to prevent possible drug-drug interactions.

3. Points of attention when using

1.Regular examination: During the period of medication, patients should receive regular comprehensive examinations from doctors, including monitoring of key indicators such as blood routine and liver and kidney function.

2.Side Effect Management: If any adverse reactions or side effects occur during use, you should report it to your doctor immediately so that the treatment plan can be adjusted in a timely manner.

3.Professional consultation: If the patient has any questions or discomfort during medication, he should contact a doctor or pharmacist for consultation in time.

Selinisol (Silvio) with its unique targeted therapeutic effect, occupies an important position in the treatment of multiple myeloma and large B-cell lymphoma. In order to ensure the therapeutic effect of the drug and patient safety, patients should strictly follow the above medication guidelines and conduct standardized treatment under the guidance of a doctor.