Can entrectinib be broken into pieces and taken?

Entrectinib (Entrectinib) is a new, orally available tyrosine kinase inhibitor (TKI), mainly used to treat solid tumors carrying NTRK1/2/3, ROS1 and ALK gene fusion mutations. It is a drug with central nervous system activity and demonstrated efficacy in primary and metastatic central nervous system diseases. The important thing is that entrectinib is not a traditional chemotherapy drug and works differently. It works by targeting cancer cells, stopping them from growing and spreading.

Regarding the way of taking entrectinib, the instructions and doctor's recommendations clearly state that it should be taken orally once a day at the same time every day. The tablet should be swallowed as completely as possible. Do not break, crush or chew the capsule. Swallow the capsule whole with a glass of water. This is because breaking the drug may destroy its sustained-release mechanism, causing the drug to be released rapidly in the body, increasing the risk of side effects, and may also affect the efficacy of the drug. Therefore the medicine should not be broken or crushed. For some patients with dysphagia, special methods can be used to take entrectinib. For example, you can put the tablets into about 30mL of warm boiled water, stir continuously until completely dissolved, and then drink the entire solution. At the same time, in order to ensure the integrity of the drug and the accuracy of the dosage, it is necessary to rinse the cup with 30mL of water and swallow all the solution.

And if the patient forgets to take a dose and it is more than 12 hours before the next dose, the patient is asked to take it as soon as he remembers. If it is less than 12 hours before your next dose, skip the missed dose and take your regular dose when the next dose is due. Do not take a double dose due to missed doses or vomiting.