How much does a box of Ribociclib cost in China?

Ribociclib (Ribociclib) is a selective cyclin-dependent kinase 4/6 (CDK4/6) inhibitors, mainly used to treat advanced or metastatic breast cancer that is hormone receptor positive and human epidermal growth factor receptor 2 negative (HR+/HER2-). The drug was developed by the Swiss company Novartis and sold under the trade name Kisqali.

Ribociclib is currently on the market in China and has been included in medical insurance. Patients can purchase it domestically at a price of about more than 8,000 yuan. Please consult the local hospital pharmacy for specific prices and medical insurance reimbursement. The cheaper one at home and abroad is the Indian version of the original drug, which costs about 3,000 yuan and has the same therapeutic ingredients as the domestic original drug.

The mechanism of action of ribociclib is to block the progression of the G1 phase of the cell cycle by inhibiting the activities of CDK4 and CDK6, thus preventing the proliferation of cancer cells. CDK4 and CDK6 play key roles in cell cycle regulation, and they are closely related to the D type Binding of cell cycle proteins drives cells from the G1 phase into the S phase for DNA replication. Riboxiclib By inhibiting this binding, the cells stay in the G1 phase and cannot continue to divide and proliferate, which is very important for controlling the spread of cancer cells.

In clinical applications, ribociclib is often used in combination with aromatase inhibitors (such as letrozole) or other endocrine therapies (such as fulvestrant). Clinical trials (such as the MONALEESA-2 study) show that ribociclib (ribociclib) combined with letrozole can significantly prolong the progression-free survival (PFS) of patients with newly treated advanced breast cancer, significantly extending the patient's disease control time. Based on these findings,ribociclib becomesHR+/HER2-First-line option for breast cancer treatment.

Common side effects of ribociclib include neutropenia, elevated liver enzymes, nausea, fatigue, and hair loss. Since this drug may cause cardiac QT interval prolongation, patients need to undergo regular electrocardiogram monitoring during use. In addition, monitoring of blood routine and liver function is also necessary to detect and manage potential adverse reactions in a timely manner.