Instructions for use of the Lao version of Sparsentan

Sparsentan, developed byTravere Therapeutics, is an innovative dual endothelin angiotensin receptor antagonist (DEARA). It protects kidney function by simultaneously inhibiting endothelin and angiotensin II, significantly reducing kidney damage and effectively reducing proteinuria. In view of the high prices of original drugs, the generic drugs launched by Lucius Pharmaceuticals in Laos provide patients with more economical treatment options. Here is a brief usage guide to the Lao version of Spasentan.

1. Drug information

Common name: sparsentine

English name:Sparsentan

Product name:LUCISETA

2. Applicable people

This product is mainly suitable for adult patients with primary IgA nephropathy (IgAN) whose disease progresses rapidly and whose urine protein to creatinine ratio (UPCR) is greater than or equal to 1.5g/g.

3. How to take

1. Initial dose: once daily, 200mg each timeorally. After 14 days, if there is no discomfort, the dosage can be increased to once a day, 400 mg each time. If treatment is interrupted, it should be restarted at a daily dose of 200 mg and adjusted to 400 mg after two weeks based on patient response.

2. How to take: It is recommended that patients swallow the tablet whole with water before breakfast or dinner, and maintain the same taking pattern as with meals.

3. Treatment course: long-term use is required, and the specific treatment course will be adjusted according to the condition and treatment effect.

4. Possible adverse reactions

Common reactions include headache, dizziness, nausea, and vomiting, which are usually mild and diminish gradually. Serious reactions, such as abnormal liver function and renal damage, should be discontinued immediately and seek medical help.

5. Notes on use

1. It is necessary to inform the doctor of the complete medical history before taking the medicine.

2. Not recommended for pregnant women. You must use effective birth control while using this medicine and for at least1 month after your last dose. If you are pregnant, tell your doctor.

3. It is prohibited for those who are allergic to this product. Allergy symptoms may include swelling of the face, lips, tongue, or throat, hives, and difficulty breathing.

4. Liver and kidney function should be checked regularly during treatment.

5. Avoid eating grapefruit products to prevent interactions with medications.

6. Drug interactions

This product may interact with other drugs (such as nonsteroidal anti-inflammatory drugs, diuretics, etc.). Please inform your doctor of any other medications you are taking when using this product.

7. Storage method

Please store medicines at room temperature, in a cool, dry place, away from direct sunlight and high temperatures, and out of the reach of children.

8. Validity period and specification price

Please confirm the expiry date of the medicine and use it within the expiry date. The specifications of the Laos Lucius version are400mg*30 tablets, and the price is about 7,000 per box.

In conclusion, the Lao version of sparsentan provides an affordable treatment option for patients with primaryIgA nephropathy. Please strictly follow the doctor's instructions and instructions when using it to ensure the safety and effectiveness of the medication. If you encounter any problems or discomfort, please seek medical advice promptly.