How much does a box of targeted drug pemetinib/pemetinib cost?

Currently, pemetinib (pemetinib) is already on the market in China, but it is not yet covered by medical insurance, and patients need to purchase it at their own expense. There are two imported versions of pemetinib on the domestic market, namely 4.5mg and 9mg specifications. The price of the former is about 30,000 yuan, and the price of the latter is about 50,000 to 60,000 yuan. As for the foreign original research version of 13.5mg specifications, the latest price of a box of 14 tablets exceeds 7 yuan.

It is worth mentioning that there are already officially launched generic pemetinib drugs on the Laos market. The ingredients of this generic drug are basically the same as those of the original drug, and its latest price is about eight to nine hundred yuan. Patients can purchase this generic drug through legal overseas channels to avoid purchasing counterfeit and substandard drugs that may affect the patient's health and safety.

Pemetinib is indicated for the treatment of unresectable locally advanced or metastatic cholangiocarcinoma in adult patients who have previously received fibroblast growth factor receptor 2 (FGFR2) fusion or other rearrangement detected by an FDA-approved test. Additionally, it is indicated for the treatment of adult patients with FGFR1rearranged relapsed or refractory myeloid/lymphoid neoplasms (MLNs).

Pemetinib belongs to a class of drugs called protein kinase inhibitors. It works by blocking the activity of receptors such as fibroblast growth factor receptors (FGFRs). Abnormal FGFRs are found on the surface of cancer cells and are involved in the growth and spread of cancer. By blocking the activity of these receptors, pemetinib reduces the growth and spread of cancer.

In a major study involving 108 patients with biliary cancer with abnormalities in FGFR2, pemetinib was effective in shrinking the cancer lesions. Approximately 37%of patients experienced cancer shrinkage that lasted an average of 8 months.