Ruxolitinib tablets/ruxolitinib price reduction in 2024

Ruxolitinib tablets/Ruxolitinib contains the active substance ruxolitinib, which is a Janus kinase inhibitor (JAK inhibitor) that is selective for JAK1 and JAK2 subtypes. Ruxolitinib inhibits JAK signaling dysregulation associated with myelofibrosis. JAK1 and JAK2 recruit cytokine receptor signal transducers and activators of transcription (STATs) to regulate gene expression. Ruxolitinib tablets is a drug used to treat the following diseases:

1. Splenomegaly or other disease-related symptoms in adults with myelofibrosis, such as fever, night sweats, bone pain, and weight loss. Myelofibrosis is a disease in which the bone marrow becomes very dense and hard and produces abnormal, immature blood cells.

2. In adults with polycythemia vera, the drug hydroxyurea (also called hydroxyurea) is ineffective or causes unacceptable side effects. In polycythemia vera, too many red blood cells are produced, which results in reduced blood flow to organs due to blood"thickening" and occasionally the formation of blood clots.

3. Acute or chronic graft-versus-host disease (when transplanted cells attack the body) occurs in people 12 years and older who have had a transplant and are not responding well to corticosteroids or other systemic treatments (oral or injected treatments).

In China, the original drug is marketed as ruxolitinib phosphate tablets and has been included in the reimbursement scope of Class B medical insurance. Common specifications include 20mg 14 tablets and 5mg 60 tablets. The price is about 3,000 yuan per box. Overseas, the price of the Turkish version of ruxolitinib's original drug, 20mg 56 tablets per box, may be around 8,000 yuan, and the specific price may change due to the exchange rate. At the same time, there are also generic drugs for sale in overseas markets, and their ingredients are basically the same as the original drugs. For example, the price of 5mg 50 tablets produced by a Bangladesh pharmaceutical factory is about more than 1,000 yuan, which will also be affected by exchange rate fluctuations.