Which side effect is more serious, Eltrombopag or Hetrombopag?

Eltrombopag (Eltrombopag) side effects:

1.Common adverse reactions: abnormal hepatobiliary laboratory test results, severe hepatotoxicity and potentially fatal liver injury. Paresthesia, rash, alopecia, dry eye, cataracts, oral ulcers, nausea, diarrhea, myalgia, muscle cramps, musculoskeletal pain, menorrhagia (the incidence of these adverse reactions ranges from >1/100 to <1/10).

2.Rare adverse reactions: fever, infection, allergy, mood changes, blurred vision, headache, dizziness, arrhythmia, dry mouth, vomiting, abdominal pain, oral bleeding, pulmonary embolism, deep vein thrombosis, pigment abnormalities, muscle weakness, abnormal renal function (the incidence of these adverse reactions<1/100).

Side effects of Hetrombopag (Hetrombopag ethanolamine tablets):

Liver problems: The main effects of eltrombopag on the liver are mild to moderate elevations in aminotransferases. Compared with eltrombopag, its risk of hepatotoxicity is lower.

Allergic Reactions: Some people may experience severe allergic reactions such as severe rash, hives, itching, redness, blisters, or flaking of the skin while taking Hetrombopag.

Thromboembolic events: Hetrombopag may cause signs of thromboembolism, such as chest pain or tightness, shortness of breath, cough, and swelling of the legs or arms.

Cataracts: Patients taking Hetrombopag for a long time may develop signs of cataracts, such as decreased vision, glare, and visual field defects.

Others: In addition to the above side effects, Hetrombopag may also cause symptoms such as headache, blurred vision, and constipation.

Eltrombopag may lead to a more serious risk of hepatotoxicity, including potentially fatal liver injury, which is one of the more prominent side effects. Although the side effects of eltrombopag also include effects on the liver and thromboembolism, they are usually manifested as mild to moderate elevations in transaminases, and may be less severe than eltrombopag. Both have some common and rare adverse effects, but eltrombopag seems to have a wider variety of side effects, covering multiple systems.