What does Osimertinib tablets do?

Osimertinib tablets, also known asAZD-9291 or Tagrisso (osimertinib), is a highly effective Selective EGFR (epidermal growth factor receptor) mutant inhibitors are mainly used to treat non-small cell lung cancer (NSCLC).

Osimertinib tablets can specifically inhibit the conduction of tumor cells and their spread to surrounding tissues and organs, thereby interfering with the proliferation, differentiation and growth of cancer cells, inducing apoptosis of cancer cells, and thus playing an anti-cancer role.

Osimertinib tablets are a third-generation EGFR-TKI (tyrosine kinase inhibitor) that targets EGFR mutations and T790M resistance mutations. EGFR mutations and T790M mutations form covalent bonds at the ATP binding site, selectively and irreversibly inhibiting tyrosine kinase phosphorylation to inhibit tumors.

Osimertinib tablets are not only used for first-line treatment of patients with epidermal growth factor receptor (EGFR) exon 19 deletion or exon 21 (L858R) substitution mutation Adult patients with advanced or metastatic non-small cell lung cancer (NSCLC) are also suitable for patients who have experienced disease progression during or after treatment with EGFRtyrosine kinase inhibitors (TKI) and the presence of EGFR has been confirmed by testing Treatment of adult patients with T790Mmutation-positive locally advanced or metastaticNSCLC.

The treatment effect of drug-resistant advanced lung cancer patients taking domestic Kemena, gefitinib (Iressa), erlotinib hydrochloride (Tarceva) is very obvious, bringing new treatment hope to these patients.

However, some adverse reactions may occur during use of osimertinib tablets, such as rash, itching, redness, difficulty breathing, swelling of lips, etc. In this case, you should stop taking it immediately and go to the hospital for treatment in time[2] At the same time, pregnant women and lactating women should use this drug with caution, and avoid taking it with carbamazepine tablets, rifampicin capsules, phenytoin tablets and other drugs.