Which organs will osimertinib affect?

Osimertinib (Osimertinib), as a highly effective targeted therapy, is mainly used to treat patients with non-small cell lung cancer (NSCLC), especially those who have developed resistance after using other EGFR inhibitors (such as gefitinib or erlotinib). However, like many other drugs, osimertinib may cause side effects during treatment that may involve multiple organ systems.

Osimertinib may have effects on the digestive system. Some patients will experience nausea, vomiting, diarrhea and other symptoms after taking osimertinib. Severe cases may require symptomatic treatment by a doctor. In addition, some patients may also experience constipation. For such patients, it is recommended to eat more foods that can speed up intestinal peristalsis or perform appropriate abdominal massage to relieve symptoms.

Osimertinib may also have effects on the skin. Some patients may experience rash or dry skin after use, which is a very common side effect of drugs. Skin rashes usually subside over time, but severe cases may require symptomatic treatment with corresponding medications.

Osimertinib may also have effects on the respiratory system. Some patients taking osimertinib may develop symptoms of interstitial lung disease such as cough and dyspnea, which need to be judged based on high-resolution CT results. If these symptoms occur, osimertinib may need to be discontinued and should not be used again.

The cardiovascular system is also one of the organs that osimertinib may affect. Some patients may experience arrhythmia, decreased cardiac ejection fraction, heart failure, myocarditis, etc. after use. These require timely consultation with a doctor and appropriate treatment measures.

In addition, osimertinib may also affect the eyes, mouth and other parts of the body. For example, some patients may experience symptoms such as dry eyes, blurred vision, and mouth ulcers.