Is Jekwei Ruxolitinib Phosphate Tablets/Ruxolitinib?

Jekev and Ruxolitinib Phosphate Tablets/Ruxolitinib are the same drug. This is a disease-specific oral drug commonly used to treat hematological diseases such as myelofibrosis (MF), polycythemia vera (PV), and graft-versus-host disease (GVHD). Ruxolitinib belongs to a class of drugs known as JAK inhibitors, which can reduce inflammation and related symptoms by inhibiting the activity of specific enzymes in signaling pathways. Jiekewei is the trade name of ruxolitinib tablets sold in China.

Ruxolitinib tablets exert its pharmacological effects by inhibiting JAK1 and JAK2 in Janus-associated kinases (JAKs), thereby blocking the JAK-STAT signal transduction and activator of transcription (STAT) pathway. The JAK-STAT signaling pathway plays a key role in cell proliferation, growth, and hematopoiesis. MF is related to the upregulation of JAK1/JAK2 signaling-specific gene expression, leading to the overall continued disorder of the JAK-STAT signaling pathway.

Before starting treatment with ruxolitinib, a complete blood cell count must be performed, and dose adjustments must be made based on platelet count. The drug is mainly metabolized by the hepatic CYP3A4 enzyme, so simultaneous administration with strong CYP3A4 inhibitors should be avoided in patients with platelet counts less than 100×10^9L.

Ruxolitinib Phosphate Tablets (Jekev) is a prescription drug that needs to be purchased and used under the guidance of a doctor. A prescription from a doctor is required when purchasing. Drug prices may vary depending on factors such as region, pharmacy, and purchase time. Ruxolitinib tablets have also been reimbursed by Class B medical insurance. Common specifications are 20mg*14 tablets and 5mg*60 tablets. The price is about 3,000 yuan per box.