How much does a box of ibrutinib/ibrutinib cost in 2024?

Ibrutinib, formerly known as PCI-32765, is a potent covalent inhibitor of Bruton's tyrosine kinase (BTK), a kinase downstream of the B cell receptor that is critical for the survival and proliferation of B cells. In preclinical studies, ibrutinib binds to Bruton tyrosine kinase with high affinity, resulting in inhibition of B cell receptor signaling, reduced B cell activation and induction of apoptosis.

In clinical studies, ibrutinib was well tolerated and showed potent anti-tumor activity in a variety of hematological malignancies, most notably chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. (MCL), which led the U.S. Food and Drug Administration (FDA) to approve relapsed CLL and MCL. In subsequent studies, ibrutinib also showed good therapeutic effects in other types of non-Hodgkin lymphoma and in combination studies with monoclonal antibodies and chemotherapy,such asWaldenströ macroglobulinemia.

The original drug of ibrutinib has been launched in China and has been included in the reimbursement list of Class B medical insurance. Patients who meet the indications can purchase it. Taking the specification of 140mg*90 tablets as an example, the price of each box may be more than 10,000 yuan; the price of the original drug sold overseas may be more than 10,000 US dollars, which is relatively more expensive. Its generic drugs are already on the market for sale overseas. The ingredients of the drugs are basically the same as those of the original drugs. Taking the generic drugs produced by Bangladesh Yaopin International as an example, the price of each box of 140mg*112 pills may be more than 2,000 yuan (the price may fluctuate due to the exchange rate).