What are the adverse reactions caused by taking osimertinib?

Some patients may experience skin problems after taking osimertinib. The specific manifestation is bullous skin disease, where blisters appear on the skin. After the blisters rupture, there may be symptoms such as erosion, scabs, or desquamation. In addition, it may also cause blackening of the skin all over the body, itching, pain, and lacerations on the skin of the fingers. You may also develop rash or dry skin, which are very common side effects of medications.

Digestive problems are also one of the common adverse reactions of osimertinib. Patients may experience symptoms such as loss of appetite, abdominal pain, diarrhea, and abnormal liver function. In addition, nausea and vomiting are also problems encountered by some patients. In severe cases, constipation may also occur, which can be relieved by eating more foods that speed up intestinal peristalsis or performing appropriate abdominal massage.

Since osimertinib may inhibit the growth of tracheal epithelial cells and aggravate the damage to lung function, patients may develop complications such as interstitial lung disease and pneumonia during use. Symptoms include coughing and difficulty breathing. When such a situation occurs, patients should promptly identify the cause and deal with it under the guidance of a doctor.

Osimertinib may also cause cardiovascular system problems, such as prolongation of the QT interval of the electrocardiogram, frequent syncope and other serious adverse reactions. At the same time, symptoms such as decreased cardiac ejection fraction and heart failure may occur, and in severe cases, myocarditis may even occur.

In addition to the above four adverse reactions, osimertinib may also cause other problems, such as reduced platelet and white blood cell counts, as well as blurred vision, cataracts and other eye discomforts. Symptoms such as oral ulcers, paronychia, and oral mucositis may also occur.