Ibrutinib/ibrutinib capsules price import in 2024

Ibrutinib/Ibrutinib is a small molecule drug sold under brands such as Imbruvica that inhibits B cell proliferation and survival by irreversibly binding to the protein Bruton’s tyrosine kinase (BTK). Blocking BTK inhibits the B-cell receptor pathway, which is often hyperactive in B-cell cancers. Therefore, ibrutinib is used to treat such cancers, including mantle cell lymphoma, chronic lymphocytic leukemia, Waldenström's macroglobulinemia, and chronic graft-versus-host disease (cGVHD).

Ibrutinib also bindsC-terminal Src kinases, which are off-target receptors for BTK inhibitors. Ibrutinib binds to these receptors and inhibits the kinases promoting cell differentiation and growth. During treatment for chronic lymphocytic leukemia, this can lead to many different side effects, such as pneumonia, upper respiratory tract infections, sinusitis, skin infections, headaches, bleeding, bruising, diarrhea, vomiting, inflammation of the lips, nausea, etc. It is on the World Health Organization's list of essential medicines.

The original drug of ibrutinib has been launched in China and has also been included in the reimbursement scope of Class B medical insurance. Taking the specification of 140 mg and 90 capsules as an example, the price of each box may be as high as more than 10,000 yuan. Overseas, the price of the same original drug may exceed US$10,000, which is relatively more expensive. It is worth mentioning that there are already generic drugs on the market overseas, and their drug ingredients are roughly the same as the original drugs. For example, the generic drug produced by Bangladesh Yaopin International has a specification of 140 mg and 112 pills, and the price per box is about more than 2,000 yuan. However, please note that the price may fluctuate due to the exchange rate.