How to deal with resistance to lung cancer targeted drug platinib

When resistance to platinib occurs, the patient's condition first needs to be re-evaluated. This includes understanding the size of the tumor, its location, whether it has metastases, etc., as well as the patient's overall health. At the same time, genetic testing is recommended to determine whether new genetic mutations or drug-resistant mutations have emerged. This information is critical for the development of subsequent treatment strategies.

Based on the results of genetic testing, if new targets or drug-resistant mutations are discovered, other targeted drugs that can target these targets can be considered. For example, for certain mutations in the RET kinase domain, in addition to platinib, other RET inhibitors such as selpercatinib may be effective. By changing the drug, the patient can continue to be treated and survive longer.

If a single targeted drug cannot effectively control the disease, a combination of other treatments can be considered. For example, targeted drugs can be used in combination with chemotherapy drugs, immunotherapy drugs, etc. to enhance the therapeutic effect. This combined treatment strategy can attack multiple targets of tumor cells, improve treatment efficacy and delay the development of drug resistance.

After resistance to targeted drugs, radiotherapy and chemotherapy are still effective treatments. Radiation therapy uses high-energy rays to kill cancer cells, while chemotherapy uses drugs to interfere with the growth and division of cancer cells. Although these methods may bring some side effects, they still have a certain effect in controlling the disease and relieving symptoms.

For patients with advanced lung cancer or patients with poor physical condition, when targeted drugs are resistant and other treatments are not suitable, supportive care and palliative care can be considered. These treatments are designed to relieve patients' symptoms and improve their quality of life, rather than directly attacking cancer cells. For example, nutritional support, pain control, psychological care, etc. can be provided.