What kind of medicine is Rubicatin and how much does it cost per box?

Lubicatin, whose full name isLurbinectedin or Zepzelca, is an innovative small molecule cytotoxic drug that provides treatment for adult patients with small cell lung cancer (SCLC). The drug was jointly developed by Jazz Pharmaceuticals and PharmaMar. Its unique mechanism of action is that it can combine with guanine residues in the minor groove of DNA to form specific adducts, leading to changes in the DNA structure, thereby affecting the activity of DNA-binding proteins and DNA repair pathways, triggering tumor cell cycle disorders and ultimately leading to cell death.

In June 2020, rubicatin was approved by the Food and Drug Administration (FDA) in the United States for the treatment of adult patients with metastatic small cell lung cancer (SCLC) who have progressed after platinum-based chemotherapy. Its efficacy is remarkable, especially in controlling disease progression and prolonging survival. According to clinical trial data, among patients treated with rubicatin, the overall response rate (ORR) reached 35.2%, the median duration of response (DOR) was 5.3 months, and the median progression-free survival (PFS) was 3.9 months.

It is worth mentioning that rubicatin is not only approved in the United States, but also recognized in many countries and regions, and has been included in multiple authoritative cancer treatment guidelines. Although Rubicatin has not yet been officially launched in China, its efficacy and safety have been widely recognized by the international medical community. For patients with small cell lung cancer, rubicatin undoubtedly provides new treatment options and hope.

For Rubicatin, which is not currently available in China, patients in need can consider purchasing it from abroad, or contact regular overseas medical consulting companies for help. Currently, only the original version of Rubicatin is available on the market. This version is manufactured by Spain's PharmanMar biopharmaceutical company and sold in Singapore and the United States. The drug is available in 4mg specifications and is priced at 91,000 yuan per box in the United States and 34,000 yuan per box in Singapore.