What is the latest selling price of Seliniso in 2024?

Seleniso has been launched in the domestic market and has been included in the medical insurance system. Its price range is wide, ranging from several thousand yuan to tens of thousands of yuan. The selling price of the original American Seleniso in overseas markets is as high as 15 more than 150,000 yuan. For patients looking for a more affordable solution, Lucius Pharmaceuticals and Daxiong Pharmaceuticals in Laos offer legal generic drug options. The ingredients of these generic versions are basically the same as those of the original drugs, and the latest market price is around three to four thousand yuan, providing more patients with affordable treatment options.

Selinesol is the world's first oral drug targeting selective nuclear export inhibitors. It cleverly blocks the extranuclear transfer of tumor suppressors, growth regulatory proteins and anti-inflammatory proteins by tightly binding to the nuclear export protein XPO1 (CRM1). This mechanism promotes the accumulation of these key proteins in the cell nucleus, enhancing their anti-cancer efficacy. This mode of action directly interferes with multiple signaling pathways and regulatory processes within tumor cells, thereby inhibiting tumor growth and viability.

A major study of402 multiple myeloma patients who had received at least one prior treatment found that selinesol given with bortezomib and low-dose dexamethasone increased the time patients lived without their disease getting worse. Patients who received this combination lived an average of 13.9 months without disease progression, compared with an average of 9.5 months for those who received the combination of bortezomib alone and low-dose dexamethasone.

Another major study involving 83 multiple myeloma patients showed that selinesol given with low-dose dexamethasone was effective in reducing cancer in patients whose disease had not improved after four previous treatments and worsened after the last treatment. One in four patients (25.3%) had cancer that lasted an average of 4 months after treatment with selinexol.