Can surgery be performed while taking acalatinib/acalabrutinib?

Acalabrutinib, also known as acalabrutinib (Acalabrutinib), is a specific drug that is widely used to treat chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL) and previously treated mantle cell lymphoma (MCL). Its main mechanism of action is to inhibit the activity of Bruton's tyrosine kinase (BTK), thereby interrupting BCR signaling, thereby inhibiting the growth and survival of malignant B-cell tumors.

However, a critical concern for patients who are taking acotinib and are considering surgery is the possible increased risk of bleeding during surgery. This is because acotinib may have a certain impact on platelet function, thereby reducing the blood's coagulation ability. Therefore, before a patient decides to undergo surgery, the medical team usually conducts a thorough assessment of the patient's risk of bleeding. Based on the type of surgery and the patient's specific condition, the physician will weigh the need to temporarily discontinue acotinib.

For some minor or minimally invasive surgeries, patients may not need to stop taking acotinib. However, for more complex or major surgeries involving critical organs, doctors often recommend stopping the drug 3 to 7 days before surgery to ensure safety during the surgery, especially to reduce the risk of bleeding. In addition, doctors will also make fine adjustments to the dosage and withdrawal time of acotinib based on the patient's personal characteristics, such as age, gender, weight, and renal function.

In addition to the risk of bleeding, patients taking acotinib may face other potential side effects during surgery, including but not limited to diarrhea, headache, upper respiratory tract infection, joint pain, and easy bruising. Although these side effects will subside naturally as treatment progresses in most cases, they may still have some impact on the recovery process after surgery. Therefore, during the preoperative preparation stage, patients should explain their health status and all the medications they are currently taking to the doctor in detail, so that the doctor can plan the surgical strategy more accurately.