Cabozantinib usage and dosage, how to take it

Cabozantinib is available in two forms. The capsule form (Cometriq) is used to treat medullary thyroid cancer and the tablet form (Cabometyx) is used to treat renal cell carcinoma, hepatocellular carcinoma and differentiated thyroid cancer. The Cometriq and Cabometyx brands have different formulas and are not interchangeable.

Cabometyx is available as an oral tablet.

Patients with advanced renal cell carcinoma who are experienced with cabozantinib tablets and patients with hepatocellular carcinoma who have been previously treated with sorafenib: The recommended dose of cabozantinib as a single agent is 60 mg once daily without food until the patient no longer experiences clinical benefit or experiences unacceptable toxicity.

Cabozantinib tablets in combination with Opdivo (nivolumab) for the first-line treatment of advanced renal cell carcinoma : The recommended dose is cabozantinib 40 mg PO once daily in combination with 240 mg nivolumab every 2 weeks or 480 mg nivolumab every 4 weeks until disease progression or unacceptable toxicity, for up to 2 years.

Cabozantinib Tablets Age of treatment >Patients 12 years of age with locally advanced or metastatic DTC who have progressed after prior VEGFR-targeted therapy and are radioiodine refractory or ineligible:

The recommended dose of cabozantinib as a single agent is 60 mg once daily in adults and pediatric patients 12 years and older with BSA greater than or equal to 1.2 m2 until disease progression or unacceptable toxicity when administered as recommended.

For In pediatric patients 12 years of age and older with a BSA less than 1.2 m2, the recommended dose of cabozantinib as a single agent is 40 mg once daily until disease progression or unacceptable toxicity when administered as recommended.

Cometriq is available as an oral capsule.

The recommended daily dose of cabozantinib capsules is 140 mg (one 80 mg capsule and three 20 mg capsules).

In summary, the dosage and administration method of Cabozantinib need to be adjusted according to the different diseases being treated, and should be strictly followed as directed by the doctor. During use, attention should be paid to drug interactions, adverse reaction monitoring, and medication safety for special groups.