What are the most serious side effects of dasatinib?

As a drug for the treatment of leukemia, dasatinib can effectively inhibit leukemia bone marrow cells, but it may also have a variety of side effects during use. Some of these side effects may be serious and require special attention.

1.Allergic reactions: Some patients may experience severe allergic reactions after using dasatinib, including skin symptoms such as rash, urticaria, itching, redness and swelling, as well as serious symptoms such as difficulty breathing, swallowing or speaking. These allergic reactions can be life-threatening, so seek medical attention immediately if they occur.

2.Increased risk of infection: Patients taking dasatinib may be more susceptible to infection. Signs of infection include fever, chills, sore throat, etc. In severe cases, it may lead to illnesses such as pneumonia. According to relevant data, pneumonia accounts for 6% of the serious adverse reactions of dasatinib.

3.Bleeding events: Dasatinib may cause abnormal bleeding, such as vomiting or coughing up blood, blood in the urine, black or tarry stools, etc. Gastrointestinal bleeding also accounts for 6% of the serious adverse reactions of dasatinib. This type of bleeding can be life-threatening and requires close attention.

4. Liver function damage: Dasatinib may cause damage to the normal liver function of the human body, and even liver failure in severe cases. Some patients will develop abnormal liver function after using dasatinib, so liver function tests need to be performed regularly during use.

5.Fluid retention: Some patients may experience fluid retention after taking dasatinib, the most common being pleural effusion. Pleural effusion accounts for a high proportion of serious adverse reactions of dasatinib (6%). Patients may experience chest tightness, shortness of breath and other symptoms, and in severe cases need to seek medical attention promptly.