What are the adverse reactions of bedaquiline?

Bedaquiline is a new type of anti-tuberculosis drug, especially in the treatment of multi-drug-resistant tuberculosis (MDR-TB). Bedaquiline exerts a powerful antibacterial effect by inhibiting the ATP synthase of Mycobacterium tuberculosis and interfering with its energy metabolism. This unique mechanism of action allows bedaquiline to combat TB strains that are resistant to traditional anti-TB drugs. Therefore, it has been included in the treatment guidelines for tuberculosis by the World Health Organization (WHO) and is widely used as a second-line anti-tuberculosis drug.

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Bedaquiline may cause serious side effects. Contact your doctor right away if you have: fast or pounding heartbeat, fluttering chest, shortness of breathand sudden dizziness (like you might pass out); chest pain; coughing up blood or vomit that looks like coffee grounds; or liver problems—loss of appetite, stomach pain (top right), tiredness, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects of bedaquiline may include: coughing up blood; chest pain; nausea, stomach pain; headache; joint pain; or abnormal liver function tests. This is not a complete list of side effects, and other side effects may occur.

However, it is important to note that bedaquiline is not guaranteed to kill all types of tuberculosis bacteria. Due to the diversity and complexity of tuberculosis bacteria, as well as possible drug resistance, bedaquiline usually needs to be used in combination with other anti-tuberculosis drugs to form a more effective treatment regimen. This combination of drugs helps reduce the occurrence of drug resistance and improves the overall therapeutic effect.

During the period of using bedaquiline, patients need to strictly follow the doctor's instructions, take the medicine on time and in the right amount, and have liver function and other related indicators monitored regularly. This is because bedaquiline has certain side effects, which may include but are not limited to liver toxicity, QT prolongation, potential serious arrhythmia, etc. Although these side effects are uncommon, if they occur, they can have serious consequences for the patient's health.

Bedaquiline inIt was approved for marketing in China on January 2, 2020, and has been included in the reimbursement scope of domestic Class B medical insurance. Its domestic specifications are 100 mg and 24 tablets, and the price is about 10,000 yuan per box after medical insurance reimbursement. It is also reported that bedaquiline is also sold in Russia, with a specification of 100mg and 188 tablets, and a price of about 16,000 yuan. For more details on the price of bedaquiline, please consult a regular overseas medical consultation service.

In general, bedaquiline is an important anti-tuberculosis drug, especially in the treatment of multi-drug-resistant tuberculosis, showing unique advantages. However, its use requires strict compliance with medical instructions and reasonable medication and treatment under the guidance of a doctor. At the same time, patients also need to fully understand the relevant information of the drug in order to better cooperate with the treatment and improve the treatment effect.