How to take vosoritide

Voxzogo (vosoritide) promotes linear growth in children with achondroplasia with open epiphyses. To reduce the risk of hypotension and its associated signs and symptoms, patients should eat enough food before treatment with Voxzogo and drink approximately 240 to 300 ml of fluids one hour before dosing.

The recommended dose of Voxzogo is based on the patient's actual body weight and is administered by subcutaneous injection once daily; the volume of Voxzogo to be administered (injection volume) is based on the patient's actual body weight and the concentration of reconstituted Voxzogo (0.8 mg/mL or 2 mg/mL). If possible, inject Voxzogo at about the same time each day. Patients' weight, growth, and physical development are regularly monitored and evaluated every 3 to 6 months.

The actual weight of the patient is 3kg, the dose is 0.096mg, and the injection volume is 0.12mL; the dose for the patient weighing 4kg is 0.12mg, the injection volume is 0.15mL; the dose for the patient weighing 5kg is 0.16 mg, the injection volume is 0.2mL; the dosage for those weighing 6-7kg is 0.2mg, the injection volume is 0.25mL; the dosage for those weighing 8-11kg is 0.24mg, the injection volume is 0.3mL; the dosage for those weighing 12-16kg is 0.28mg, the injection The dosage is 0.35mL; the dosage for people weighing 17-21kg is 0.32mg, the injection volume is 0.4mL; the dosage for people weighing 22-32kg is 0.4mg, the injection volume is 0.5mL; the dosage for people weighing 33-43kg is 0.5mg, the injection volume is 0.25mL; the dose for those weighing 44-59kg is 0.6mg, the injection volume is 0.3mL; the dose for those weighing 60-89kg is 0.7mg, the injection volume is 0.35mL; the dose for those weighing ≥90kg is 0.8mg, the injection volume is 0.4mL.

Before preparing to inject Voxzogo, patients need to remove the Voxzogo vial and prefilled diluent syringe from the refrigerator and allow them to warm to room temperature. Inject Voxzogo into the front of the thigh, buttock, or anywhere on the abdomen except for the belly button (belly button) and the 2-inch area around it. The outside area of u200bu200byour upper arm can also be used if another person is injecting your medication. Do not inject this medication into tender, bruised, damaged, or scarred skin. Choose a different location each time you inject the medication.

If a dose is missedVoxzogo can be administered within 12 hours of the scheduled dose. After 12 hours have elapsed, skip the missed dose and take the next daily dose according to the usual dosing schedule. Adjust the dose based on the patient's actual body weight and permanently discontinue Voxzogo after confirmation of no further growth potential (as indicated by epiphyseal closure).