How much does it cost to buy a box of lorlatinib/lorlatinib tablets in 2024?

Lorlatinib, which contains the active substance lorlatinib, is a cancer drug used to treat adult patients with advanced and ALK-positive non-small cell cancer (NSCLC), which means that the cancer cells have certain changes that affect the gene for a protein called ALK (anaplastic lymphoma kinase).

Lorlatinib may be used alone when the disease has not been previously treated with other drugs of the same class, called ALK tyrosine kinase inhibitors (TKIs). Despite treatment with other ALK TKIs, including alectinib, ceritinib, and crizotinib, lorlatinib may also be used alone when disease progression occurs.

Lorlatinib is available by prescription only, and treatment should be initiated and supervised by a doctor experienced in using cancer drugs; patients' cancers should be tested to confirm that they have genetic changes that affect ALK before starting treatment. Larlatinibis available as oral tablets, and the recommended dose is 100 mg once daily. If certain side effects occur, your doctor may reduce the dose or temporarily interrupt treatment. If the condition worsens or side effects become too severe, treatment may be stopped entirely.

The name of the original drug currently on the market in China is lorlatinib tablets, and it has also been included in the reimbursement list of Class B medical insurance. The common specifications are25mg*90 tablets and 100mg*30 tablets. The price of each box may range from 20,000 yuan; the price of the Hong Kong original version may range from 30,000 to 50,000 yuan, and the price of the Turkish original version sold overseas may be around 10,000 yuan. In addition, there are also cheap generic drugs sold overseas, and the ingredients of the drugs are basically the same as those of the original drugs. Taking the drugs produced by relevant pharmaceutical factories in Laos as an example, the price of each box of 100mg*30 tablets may be around 2,000 yuan (the price may fluctuate due to the exchange rate).