What to do after cabozantinib resistance?

When patients develop resistance to cabozantinib, they should first go to the hospital for detailed examination. These examinations may include but are not limited to imaging examinations, blood tests, etc., in order to accurately assess the patient's condition and drug resistance status. By fully understanding the patient's specific condition, doctors can develop more precise follow-up treatment plans for them.

Depending on the patient's specific condition and drug resistance, doctors may recommend switching to other effective anti-tumor drugs. For example, for patients with kidney cancer, you can consider switching to drugs such as axitinib and everolimus; for patients with thyroid cancer, you can try lenvatinib, sorafenib, etc.

In some cases, doctors may consider a combination strategy to enhance treatment effectiveness and overcome resistance. This often involves combining cabozantinib with other drugs to produce better anti-tumor effects.

Under the advice and guidance of a doctor, you can consider increasing the dosage of cabozantinib, but generally it should not exceed the daily limit of 80mg. At the same time, patients need to be closely monitored for reactions and side effects.

While adjusting the treatment plan, patients also need comprehensive attention and supportive care. This includes psychological support, nutritional support and management of possible side effects. Psychological support can help reduce patients' anxiety and depression and improve their treatment compliance; nutritional support can ensure that patients maintain good physical condition during treatment; and side effect management aims to reduce or eliminate the discomfort caused by treatment.

After adjusting the treatment plan, patients need regular follow-up and monitoring. This helps to identify and deal with any potential problems or complications promptly, ensuring maximum effectiveness of treatment. At the same time, doctors can further adjust and optimize the treatment plan based on the patient's response and changes in condition.