How much does it cost to take molotinib/mometinib for one month?

Momelotinib is an oral medication indicated for the treatment of moderate or high-risk myelofibrosis (MF), including primary and secondary MF (eg, post-polycythemia vera and post-essential thrombocythemia). Molotinibis a once-daily oral JAK1/JAK2 and activin a receptor type 1 (ACVR1) inhibitor. To date, it is the only drug approved for use in patients with newly diagnosed and previously treated myelofibrosis anemia that addresses key manifestations of the disease, namely anemia, constitutional symptoms, and splenomegaly (enlarged spleen).

Before and during the use of molotinib, patients need to have platelet complete blood counts (CBC) and liver function tests regularly to monitor their health. The recommended dose of molotinib is 200 mg daily, which can be taken with food. This medication is available in tablet form, and patients are required to swallow the tablets whole and not cut, crush, or chew them. If a dose is missed, it is recommended to take the next dose as usual the next day.

The common specifications currently on the market are100mg*30 tablets, 150mg*30 tablets, and 200mg*30 tablets. Since the original drug of molotinib has not yet been launched in the Chinese market, it cannot be included in medical insurance, which brings a financial burden to patients. In overseas markets, the price of original drugs is quite expensive, reaching 200,000 yuan per box, and the price will change due to exchange rate fluctuations. This puts many patients under greater financial pressure. Take the specification of 200mg*30 tablets as an example, then the monthly cost is roughly the price of one box.

In response to this situation, generic drugs of molotinib have appeared on the market. For example, the price of 100mg*30 tablets of generic drugs produced by Lucius Pharmaceuticals in Laos is relatively low, about more than 2,000 yuan per box. A rough calculation of the monthly cost requires the purchase of two boxes. The ingredients of this generic drug are close to the original drug, providing patients with a more economical choice.