Tepotinib (TEPMETKO) Quick Medication Guide for Patients

Tepotinib (trade name: Tudekan/TEPMETKO) is a targeted therapy drug specially designed for patients with non-small cell lung cancer (NSCLC) with specific gene mutations. In order to ensure the best effect of the medicine and ensure patient safety, the following is a concise quick medication guide, please follow it strictly.

1. Applicable objects

Tepotinib is suitable for adult patients with metastatic non-small cell lung cancer whose tumors must have specific gene characteristics of mesenchymal epithelial transition(MET) exon 14 skipping changes.

2. Medication time and method

1. Tepotinib should be taken once a day, and it is recommended to take it with food to reduce gastric discomfort.

2. The recommended dose is450 mg (i.e. 2 tablets), but please be sure to follow your doctor’s advice and do not change the dose on your own.

3. The tablets must be swallowed whole. Do not chew, crush or split them to avoid affecting the effect of the medicine.

4. Try to take the medicine at the same time every day to maintain the stability of the drug concentration in the body.

3. Measures to deal with missed doses and vomiting

1. If you miss a dose, take it as soon as possible. However, if the next dose is less than 8 hours away, skip the missed dose and take the next dose at the originally planned time.

2. When you vomit after taking the medicine, there is no need to take a supplementary dose. You only need to continue taking the next dose according to the original planned time.

4. Dosage adjustment and side effects treatment

1. Do not adjust the dosage or stop taking the medicine by yourself unless instructed by your doctor.

2. In case of severe side effects, the doctor may adjust the dose, temporarily stop the medication, or permanently discontinue the medication.

5. Precautions for drug interactions

1. Tepotinib may interact with other drugs, including prescription drugs, over-the-counter drugs, vitamins, and herbal medicines.

2. Before starting or stopping any medication, be sure to inform your doctor so that the doctor can evaluate whether the treatment plan needs to be adjusted.

3. Special attention should be paid to avoid simultaneous use withP-gp substrate, because even small changes may cause serious or life-threatening toxic reactions.

In short, strictly following doctor's recommendations and quick medication guidelines is the key to ensuring the therapeutic efficacy and safety of tepotinib. If you have any questions or discomfort, please communicate with your doctor in time. Currently, there are many versions of this drug available, please choose appropriately according to your personal needs.