How much does dabrafenib/dabrafenib and trametinib cost per month?

Dabrafenib and trametinib are often used together to treat certain melanoma (cancers), non-small cell lung cancer, thyroid cancer Adenocarcinoma (anaplastic thyroid cancer), solid tumor (adults and children 6 years and older), low-grade glioma (children 1 year and older), these conditions may not be treatable with surgery or may have spread to other parts of the body, or may worsen (progress) and leave no other treatment options. Doctors will test for the BRAF V600E gene mutation to ensure the drug is suitable for patients.

According to the clinical labeling guidelines for dabrafenib and trametinib, treatment must be initiated and supervised by a physician experienced in the use of cancer drugs, which are available by prescription only. Taking adult patients as an example, the recommended dose of dabrafenib is 150 mg taken orally twice a day, with 50 or 75 mg capsules each time, and the specification per box is 75 mg*120 capsules , you need about one box a month; the recommended dose of trametinib is 2 mg once a day, with 0.5, 1 or 2 mg tablets used each time, and each box is 2 mg*30 tablets, and you need about one box a month.

The two original drugs, dabrafenib and trametinib, have been launched in China and are covered by medical insurance. Each box of dabrafenib may be sold for more than 10,000 yuan, and each box of trametinib may be sold for more than 10,000 yuan. Patients may need more than 20,000 yuan for one month's use. The expensive price may increase the financial burden of families with greater financial pressure. In addition to the original drugs, there are also generic drugs of dabrafenib and trametinib on the overseas market. Their drug ingredients are basically the same as the original drugs. For example, the price of dabrafenib sold by Laos pharmaceutical factories may be more than 2,000 yuan per box, while the price of trametinib may be more than 1,000 yuan per box (prices may fluctuate due to exchange rates).