The latest price list of the targeted drug trametinib in 2024

Trametinib (Trametinib) is a kinase inhibitor used alone or in combination with dabrafenib to treat patients with cancers with specific BRAF mutations, such as melanoma and non-small cell lung cancer. BRAF V600E or V600K mutations must be detected by an FDA-approved test. Due to known intrinsic resistance to BRAF inhibition, trametinib is not indicated for the treatment of patients with colorectal cancer.

In melanoma and non-small cell lung cancer with theBRAF V600 mutation, there is an abnormal form of the BRAF protein that turns on another protein called MEK that is involved in stimulating cell division. This causes cancer to develop by allowing cells to divide uncontrollably. Trametinib, the active ingredient in trametinib, works by blocking MEK and preventing BRAF from activating MEK, thereby slowing the growth and spread of cancer.

Trametinib, alone or in combination with dabrafenib, has shown clinically relevant benefits in patients with cancer or melanoma that has spread or is unresectable. The agency also found it was beneficial in patients with advanced melanoma that had been surgically removed. The side effects of dabrafenib are considered acceptable and can be controlled with appropriate measures. Common side effects are rash, diarrhea, fatigue, peripheral edema (especially ankle and foot swelling), nausea, and acneiform dermatitis.

The original drug of trametinib has been launched in China and has been included in the medical insurance system, but only patients with specific indications can apply for medical insurance reimbursement. The specifications of the medicine include 2mg 30 tablets and 0.5mg 30 tablets, priced at around RMB 10,000. At the same time, each box of the Turkish version of the original drug overseas is priced at about 7,000 yuan, and the specific price may be adjusted due to exchange rate changes. It is worth mentioning that generic drugs of trametinib have also been launched overseas, and their ingredients are almost the same as the original drug. The price of generic drugs produced in Laos is very affordable, with each box costing only more than 1,000 yuan, but the price may also change with the exchange rate.