How to administer melphalan/melphalan for injection

Melphalan flufenamide for injection is indicated for the treatment of relapsed or refractory multiple myeloma (MM) in adult patients who have received at least four prior therapies and have demonstrated resistance to at least one proteasome inhibitor, immunomodulators, andCD38-directed monoclonal antibodies. This drug is often combined with dexamethasone (Dexamethasone) to increase its effectiveness.

In terms of medication, the recommended dose of melphalan for injection is 40 mg, which needs to be injected intravenously on the first day of each 28-day cycle. The injection time should be controlled within 30 minutes until the disease progresses or unacceptable toxic reactions occur. At the same time, patients need to take 40 mg of dexamethasone orally or intravenously on days 1, 8, 15, and 22 of each cycle. In elderly patients 75 years and older, the dexamethasone dose should be reduced to 20 mg to reduce the risk of possible side effects.

Before starting and during treatment with injectable melphalan, it is recommended thata 5-hydroxytryptamine-3 (5-HT3) receptor antagonist or other antiemetics be provided to prevent the potential for nausea and vomiting, which are common side effects of chemotherapy.

Since injectable melphalan may cause adverse reactions, the dose needs to be adjusted according to the patient's specific conditions during treatment. If serious side effects occur, your doctor will adjust the drug dose accordingly. For example, on day 1 of the first 28-day cycle, if the patient cannot tolerate the 40 mg dose, the first dose can be reduced to 30 mg; if discomfort persists after the second dose, it can be further reduced to 20 mg. For those patients who cannot tolerate the 20 mg dose, permanent discontinuation of melphalan therapy should be considered to avoid further deterioration of their health.

In summary, the dosage method of melphalan for injection/melphalan needs to strictly follow the recommended dosage, and careful monitoring and adjustment should be made during the treatment process to ensure patient safety and therapeutic effect.