Larotrectinib (VITRAKVI/VITRAKVI) Brief Instructions for Use

Larotinib (trade name: VITRAKVI/VITRAKVI), as an innovative targeted anti-cancer drug, has attracted much attention for its significant efficacy in NTRK gene fusion-positive solid tumors. As a TRK (neurotrophic factor receptor kinase) inhibitor, larotrectinib effectively interferes with the growth and division of cancer cells by blocking the abnormal protein activity produced by NTRK gene fusion, thereby providing new treatment hope for patients. This guide will briefly introduce the use and precautions of larotrectinib to help patients better understand this drug.

1. Usage and dosage:

The recommended dose of larotrectinib needs to be adjusted based on the patient's age, weight and body surface area. For adults and pediatric patients with a body surface area greater than 1.0 square meters, the recommended daily dose is 100 mg orally twice daily until disease progression or unacceptable toxicity occurs. For pediatric patients whose body surface area is less than 1.0 square meters, the recommended daily dose is 100 mg/m² orally twice, which can be taken with or without food according to the actual situation.

2. Storage and preparation:

Larotrectinib capsules should be storedat room temperature between 20°C and 25°C (68°F and 77°F), away from direct sunlight and moisture. Oral liquids need to be stored in a refrigerator at 2°C to 8°C (36°F to 46°F). They should be used within 90 days after first opening the bottle. Unused oral liquids should be discarded and no longer used. When using capsules, swallow them whole and avoid chewing or crushing. Oral solutions need to be taken with the aid of an oral syringe.

2. Things to note:

1. Gene testing: Before using larotrectinib, patients should undergoNTRK gene fusion testing to confirm whether they are suitable for this drug treatment.

2. Side effect monitoring: Common side effects include nausea, vomiting, diarrhea, constipation, cough, dizziness, fatigue, etc. Although serious side effects are rare, if symptoms such as severe allergic reactions or abnormal liver function occur, you should seek medical attention immediately.

3. Drug Interactions: Inform your doctor of all medications you are taking, including prescription drugs, over-the-counter drugs, vitamins, and herbal supplements, to avoid drug-drug interactions.

4. Specific groups: Pregnant and lactating women should inform their doctor about the situation as it may cause harm to the fetus or baby.

In short·,Larotinib, as a targeted anti-cancer drug targeting specific gene fusions, provides a new treatment option for many patients. During use, patients should strictly follow the doctor's instructions, take the medicine on time and in the right amount, and pay attention to observing the body's reaction. At the same time, maintain close communication with the doctor and provide timely feedback on any discomfort or side effects to ensure the safety and effectiveness of the treatment.