People who take pirfenidone/isre are getting thinner and thinner

Pirfenidone/As a drug used to treat idiopathic pulmonary fibrosis (IPF), although Pirfenidone has certain efficacy in delaying the progression of the disease, its side effects may cause patients to experience weight loss and weight loss. Weight loss is a complex physiological response involving multiple factors. The following are some reasons that may cause people to become increasingly thin after taking pirfenidone.

One of the common side effects of pirfenidone is digestive system reactions, such as nausea, vomiting, and diarrhea. These gastrointestinal symptoms may cause patients to lose their appetite, causing them to eat less food. During the medication period, patients may reduce eating due to aversion to food or discomfort, which affects overall nutritional intake and ultimately leads to weight loss. If patients fail to adjust their diet or seek medical advice promptly, their weight changes may be more pronounced.

Pirfenidone use may cause fatigue and weakness, which are major side effects reported by many patients. This persistent feeling of fatigue may cause patients to reduce daily activities, including exercise and participation in social activities, resulting in changes in overall metabolic rate. In this condition, patients may have difficulty maintaining a normal weight due to a lack of exercise and moderate activity. In addition, fatigue may also affect the patient's mental state, causing them to lack motivation and interest when eating.

Furthermore, pirfenidone may affect liver function. Some patients may experience an increase in liver enzyme levels during medication, which may lead to a decrease in liver metabolism and further affect the absorption and utilization of nutrients. Impairment of liver function may result in the body's inability to store and metabolize nutrients efficiently, resulting in energy deficits that manifest as weight loss and wasting.