What is Rubicatin/Rubicatin?

鲁比卡丁/卢比替定（Lurbinectedin）是一种选择性致癌转录抑制剂，用于治疗在铂类化疗期间或之后出现疾病进展的转移性小细胞肺癌（SCLC）成年患者。根据在一项开放性单药治疗临床试验中证明的总体缓解率（ORR）和反应持续时间（DoR），Zepzelca获得加速批准。 Continued approval for this indication may be contingent upon verification and characterization of clinical benefit in confirmatory trials.鲁比卡丁是从海鞘Ecteinacida turbinata中分离的海洋化合物ET-736的类似物。

鲁比卡丁是自1996年以来第一个被批准用于二线治疗的新药。 Small cell lung cancer remains a major unmet medical need.鲁比卡丁通过静脉输注给药60分钟，通常每21天给药一次。 Preoperative use of corticosteroids (such as dexamethasone) and serotonin antagonists (such as ondansetron) may prevent nausea and vomiting. Common side effects include fatigue, anemia, nausea, decreased appetite, musculoskeletal pain, constipation, dyspnea, vomiting, cough, and diarrhea.鲁比卡丁可导致严重的副作用，包括骨髓抑制、肝毒性和胚胎-胎儿毒性。

The original drug of Rubicatin has not yet been launched in China, and has not been included in medical insurance. The original version currently sold in Hong Kong, specifications The price of each 4mg tube may be more than 20,000 yuan (the price may fluctuate due to the exchange rate); currently There are multiple versions of the original rubicatin drug available overseas. The price of the US version is about more than 90,000 yuan, and the price of the Singapore version is about more than 30,000 yuan (the price may fluctuate due to exchange rates).海外也没有鲁比卡丁仿制药上市出售。