Potential risks and effects of long-term use of baricitinib

The potential risks and effects of long-term use of baricitinib cannot be ignored. As a drug for the treatment of autoimmune diseases such as rheumatoid arthritis, baricitinib has certain efficacy, but its side effects are also quite obvious.

The risk of infection is one of the important issues faced by long-term use of baricitinib. This drug may induce a variety of infections, including tuberculosis, invasive fungal infections, and infections caused by opportunistic pathogens. These infections can sometimes become serious and even life-threatening. Therefore, patients should remain highly vigilant during the use of baricitinib and seek medical attention immediately if symptoms of infection occur.

Blood problems are also aspects that need to be paid attention to during long-term use of baricitinib. This drug may cause an increase in platelets, causing the blood to become hypercoagulable, increasing the risk of blood clots. Serious complications such as deep vein thrombosis and pulmonary embolism can occur. To avoid these risks, patients need to have regular blood tests and take necessary precautions under the guidance of their doctor.

Abnormal liver function is also a possible problem with long-term use of baricitinib. Since the drug is mainly metabolized by the liver, long-term use may increase the burden on the liver and lead to abnormal liver function. Patients may have elevated levels of alanine aminotransferase, aspartate aminotransferase and other indicators. Therefore, during medication, patients should regularly monitor liver function and be careful to avoid drinking alcohol and using other drugs that may cause damage to the liver.

In addition to the above risks, long-term use of baricitinib may also cause adverse effects such as allergic reactions, increased cholesterol levels, and induction of malignant tumors. Some patients are allergic to drug ingredients and may develop allergic symptoms such as rash and itching after use. At the same time, drugs may also affect lipid metabolism, leading to increased cholesterol levels. What’s more serious is that baricitinib may induce the occurrence of malignant tumors such as lymphoma, especially in patients with tumors themselves.

References:

https://arthritis.ca/treatment/medication/medication-reference-guide/medications/baricitinib