Mobosetinib/Mobosetinib How much does a box of medicine cost?

Mobocertinib/Mobocertinib is an oral tyrosine kinase inhibitor (TKI) that selectively targets epidermal growth factor receptor exon 20 insertion (EGFRex20ins) mutations. It is a structural analog of the third generation TKIosimertinib (osimertinib) targeting EGFR T790M mutant non-small cell lung cancer (NSCLC); however, mobosetinib achieved selectivity for the EGFRex20ins mutant relative to wild-type (WT) by interacting with the C790 gatekeeper residue of EGFR. This is accomplished through the carboxylated isopropyl ester moiety at the C5 position of the central pyrimidine core of mobosetinib.

In Phase 1/2 dose escalation and dose expansion studies, the investigator-confirmed overall response rate (ORR) of mobotinib was found to be 56% (9/16; 95% CI: 30-80%) and 25% (3/12; 95% CI: 5-57%) for patients without and with baseline brain metastases, respectively. The median investigator-assessed progression-free survival (mPFS) was 10.2 months (95% CI: 5.6-not reached) and 3.7 months (95%CI: 1.8-15.9), respectively. Treatment-emergent adverse events (TEAEs) associated with mobosetinib are similar to those with other EGFR inhibitors, primarily gastrointestinal (e.g., diarrhea, nausea, vomiting) and skin (e.g., rash).

The original drug of mobosetinib has been launched in the domestic market, but has not yet been included in the medical insurance system. Currently, the mainstream 40mg 112-capsule specification on the market costs about 40,000 yuan per box, which is indeed quite expensive. In Hong Kong, the clinical version of 40mg and 30 capsules costs about more than 7,000 yuan per box, but it should be noted that exchange rate changes may cause price fluctuations. At the same time, generic drugs of Mobotinib are also sold overseas, and their ingredients are similar to the original drug. For example, a 40mg*120-tablet medicine produced by a pharmaceutical factory in Laos may cost only more than 4,000 yuan. Of course, this price may also fluctuate due to the exchange rate.