What are the side effects of Tucatinib?

As a targeted drug, Tucatinib is mainly used to treat patients with HER2-positive metastatic breast cancer. It is also being studied for chemotherapy-refractory HER2-positive metastatic colorectal cancer. Although the drug has shown significant efficacy and high safety in clinical trials, some side effects may still occur during use. Here are some common side effects that may occur with tucatinib:

Gastrointestinal reactions: including nausea, vomiting, diarrhea, indigestion and other symptoms. These reactions may affect the patient's appetite and nutritional intake, thereby affecting physical recovery and treatment effects.

Skin and mucous membrane reactions: such as redness, pain, swelling, or rash, blisters, oral ulcers, etc. on the palms or soles of the feet. These symptoms may cause discomfort to the patient and may affect the patient's quality of daily life.

Nervous system problems: A small number of patients may experience symptoms such as dizziness, difficulty concentrating, headaches, and insomnia. These symptoms are usually temporary, but should be reported to a doctor for prompt evaluation and treatment.

Abnormal liver function: Tucatinib use may result in elevated liver enzymes, suggesting impaired liver function. Prolonged or severe hepatotoxicity may lead to liver failure. Liver function needs to be monitored regularly during treatment, and drug dosage should be adjusted or discontinued in a timely manner.

Cardiotoxicity: Some patients may develop symptoms such as tachycardia, arrhythmia, or heart failure. Cardiac monitoring and examinations should be performed regularly during treatment, and drug dosage should be adjusted or discontinued if necessary to protect heart function.

Other side effects include fatigue, decreased appetite, anemia, rash, affecting male and female fertility, etc. These symptoms may vary from person to person and may vary in severity.

References:

https://www.drugs.com/sfx/tukysa-side-effects.html