Does brigatinib or lorlatinib have more side effects?

When comparing the side effects of brigatinib and lorlatinib, it is necessary to comprehensively consider the incidence, severity, and impact on quality of life of both adverse reactions.

Brigatinib is a second-generation ALK inhibitor with relatively clear side effects. Common side effects include digestive system reactions such as nausea, diarrhea, or vomiting, which occur in about 30% of patients but are usually mild and can be relieved by medications or dietary modifications. In addition, about 10% of patients may develop interstitial lung disease, which is a serious side effect and requires timely medical evaluation. Abnormal liver function is also a potential side effect of brigatinib, and approximately 15% of patients may experience elevated liver enzymes. Other aspects, such as hematological effects (anemia or neutropenia) as well as skin rash, hyperglycemia, and fatigue, may also occur in some patients.

Lorlatinib, as a third-generationALK inhibitor, has significant efficacy, but its side effects are also relatively prominent. Lorlatinib may cause adverse reactions to the central nervous system, such as peripheral neuropathy, cognitive impairment, mood disorders, etc., and these symptoms are more obvious in some patients. In addition, the endocrine system may also be affected, manifesting as metabolic abnormalities such as hypercholesterolemia and hyperglycemia. In terms of the digestive system, lorlatinib may cause gastrointestinal reactions such as nausea, vomiting, and diarrhea. At the same time, it may also irritate the respiratory system, causing symptoms such as coughing and difficulty breathing. In terms of neuromusculoskeletal aspects, some patients will experience joint pain, muscle pain and other symptoms.

Generally speaking, brigatinib and lorlatinib have different side effects. The side effects of brigatinib are relatively concentrated on the digestive system, lungs and liver function, while the side effects of lorlatinib more widely involve the central nervous system, endocrine system, digestive system and other aspects. In terms of severity, both may cause more serious adverse reactions, but the impact of lorlatinib on the central nervous system may be more significant.

References:

1.https://www.drugs.com/sfx/brigatinib-side-effects.html

2.https://www.drugs.com/sfx/lorlatinib-side-effects.html