What disease is the targeted drug Lipuroolaparib tablets used to treat, and how much does it cost?

Olaparib tablets, trade name LYNPARZA (LYNPARZA), is an innovative poly ADP-ribose polymerase (PARP) inhibitor targeted drug. It inhibits the activity of PARP enzyme and interferes with the DNA repair mechanism of cancer cells, thereby promoting cancer cell apoptosis. Lynparza has shown significant efficacy in treating cancers carrying specific genetic mutations, providing many patients with new treatment options and hope for survival.

Lynparza tablets are mainly used to treat a variety of cancers, including:

1. Maintenance treatment for adult patients with gBRCAm gene mutations in advanced epithelial ovarian cancer, fallopian tube cancer, or primary peritoneal cancer who have achieved complete or partial response to first-line platinum-based chemotherapy.

2. In combination with bevacizumab, for the maintenance treatment of adult patients with advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer associated with homologous recombination deficiency (HRD).

3. Maintenance treatment of adult patients with recurrent ovarian, fallopian tube, or primary peritoneal cancer who are in complete or partial response to first-line platinum-based chemotherapy.

4. Adjuvant treatment for HER2-negative high-risk early breast cancer patients with gBRCAm gene mutations who have received neoadjuvant chemotherapy.

5. Treatment of HER2-negative metastatic breast cancer patients with gBRCAm gene mutations receiving chemotherapy in the neoadjuvant, adjuvant, or metastatic setting.

6. Maintenance therapy for adult patients with metastatic pancreatic cancer who havegBRCAm gene mutations.

7. Treatment of adult patients with metastatic castration-resistant prostate cancer (mCRPC) with HRR gene mutations.

Regarding the price of Lynparza tablets, the original drug has been launched in my country. The price of a box is about several thousand yuan. You need to consult the local pharmacy for the specific price. However, this price is still high for many patients. Fortunately, patients who qualify for reimbursement can enjoy medical insurance reimbursement benefits, thereby easing the financial burden. In addition, affordable generic versions are also sold overseas, such as olaparib tablets launched by Lucius Pharmaceuticals in Laos. A box of 150mg*120 tablets sells for about 2,000 yuan, which is relatively more affordable.

In short, Lynparza tablets, as an innovative targeted therapy, provide new treatment options and hope for survival for cancer patients carrying specific gene mutations. Although the price of original drugs is higher, medical insurance reimbursement and overseas generic versions provide patients with more economic choices. When choosing drugs, patients should consult a professional doctor based on their own condition and financial conditions to choose the treatment plan that best suits them.

Reference materials:https://www.drugs.com/pro/lynparza.html#s-43684-0