What drugs does Pitobrutinib interact with?

Pitobrutinib is a new type of targeted drug mainly used to treat specific types of blood cancers. Specifically, it is indicated for adult patients with relapsed or refractory mantle cell lymphoma (MCL) after at least two systemic therapies, including BTK inhibitors, as well as patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). This drug exerts a therapeutic effect by inhibiting the activity of Bruton's tyrosine kinase (BTK) and interfering with the growth and survival of tumor cells.

However, patients need to be aware when taking pitobrutinib that the drug may interact with other drugs, affecting the therapeutic effect or increasing the risk of side effects. Therefore, it is crucial to inform your healthcare provider of all medications you are taking, including prescription drugs, over-the-counter drugs, vitamins, and herbal supplements.

Pitobrutinib interacts with the following drugs:

PowerfulCYP3A inhibitors: such as cobicistat, ritonavir, itraconazole, ketoconazole, etc. These drugs, when used concomitantly with pitobrutinib, may increase the systemic exposure of pitobrutinib, thereby increasing the risk of adverse reactions.

Strong and moderateCYP3A inducers: such as apalutamide, carbamazepine, enzalutamide, bosentan, cinobamate, etc. These drugs may decrease the plasma concentrations of pitobrutinib, thereby affecting its efficacy.

In addition, pitobrutinib may interact with grapefruit juice. Although the effects of different brands of grapefruit juice vary, patients should still drink it with caution.

To ensure the safety and effectiveness of the medication, patients should closely monitor any abnormal reactions while taking pitobrutinib and communicate with their healthcare provider in a timely manner. At the same time, take medications strictly as directed by your doctor and avoid adjusting the dosage or changing the medication method on your own.

xa0

Reference: https://www.drugs.com/pirtobrutinib.html