What are the side effects of tucatinib, capecitabine, and trastuzumab?

Tucatinib, capecitabine, and trastuzumab are all drugs used to treat cancer, but they have different mechanisms of action and side effects.

Tucatinib is a targeted drug used to treatHER2 positive breast cancer. Common side effects include:

Gastrointestinal reactions: diarrhea, nausea, vomiting, abdominal pain, etc.

Skin reaction: redness, pain, swelling, or rash, blisters, mouth ulcers, etc. on the palms or soles of the feet.

Abnormal liver function: May cause elevated levels of liver function test indicators, and in rare cases may lead to severe liver disease.

Other side effects: fatigue, headache, anemia, rash, etc.

Capecitabine is an oral chemotherapy drug used to treat colorectal cancer and advanced breast cancer. Common side effects include:

Gastrointestinal reactions: diarrhea, nausea, vomiting, abdominal pain, decreased appetite, etc.

Hand-foot syndrome: numbness, hypoesthesia, paresthesias, and tingling on the skin of the hands and toes.

Myelosuppression: Decrease in white blood cells, platelets, neutrophils and other indicators. In severe cases, infection may occur.

Skin reactions: erythema, hair loss, rash, etc.

Other side effects: abnormal taste, insomnia, confusion, encephalopathy, ataxia, dysphonia, etc.

Trastuzumab is a targeted drug used to treatHER2 positive breast and gastric cancers. Common side effects include:

Cardiotoxicity: May lead to decreased cardiac function, arrhythmia, hypertension, heart failure, etc.

Infusion reactions: fever, chills, rash, etc., especially during the first infusion.

Gastrointestinal reactions: diarrhea, nausea, vomiting, abdominal pain, etc.

Rash: There will be an inflammatory reaction in the skin, and rashes are more likely to occur.

Other side effects: fatigue, headache, back pain, chest pain, cold-like symptoms, anxiety, depression, dizziness, insomnia, abnormal sensation, drowsiness, respiratory symptoms (such as increased cough, nosebleeds, asthma, etc.), hematological symptoms (such as leukopenia, thrombocytopenia, and anemia), etc.

References:

https://www.macmillan.org.uk/cancer-information-and-support/treatments-and-drugs/tucatinib-trastuzumab-and-capecitabine