What is the recommended dose of brigatinib for the treatment of lung cancer?

As a targeted drug for the treatment of lung cancer, the recommended dose of brigatinib is not measured in units of “pellets” but in milligrams (mg). However, if you convert it into tablets of common specifications, you can have a rough idea of u200bu200bthe number of "pills" for the recommended dosage.

For patients with newly diagnosedALK-positive metastatic non-small cell lung cancer (ALK+ NSCLC), the recommended starting dose is usually 90 milligrams (mg) once daily orally. If the tablet strength of brigatinib is 90 mg per tablet, the starting dose is 1 tablet per day. After observation and monitoring, the dose can be gradually increased after 7 to 14 days if the initial dose is well tolerated by the patient. The recommended Phase II dose is 180 mg orally once daily. If the tablet size of brigatinib is 90 mg per tablet, then the dosage at this stage is equivalent to 2 tablets per day.

If the patient is stable and well tolerated at the dose of 180 mg, the doctor may consider further increasing the dose to 240 mg once daily, that is, if the tablet size is 90 mg, it is equivalent to nearly 2.67 tablets per day (in actual operation, it may be necessary to split the tablets or use tablets of different sizes to achieve precise dosage).

For those patients who cannot tolerate the 240 mg dose, doctors can lower the dose. For example, drop to 180 mg (2 pills daily, if the tablet strength is 90 mg) or lower. There is an adjustment plan to reduce the dosage to 120 mg once a day, orally. If the tablet size is 90 mg, it is equivalent to 1.33 tablets per day (actual operation may require splitting the tablets).

If a patient suspends medication due to side effects, treatment should be restarted after adjusting the dose after ruling out other potential causes or taking into account an appropriate rest period.

Importantly, the exact dose of brigatinib should be determined by the physician based on the patient's specific condition. Patients must strictly follow the doctor's instructions on taking medications and undergo regular physical examinations and related examinations. In addition, the actual specifications of the tablets may vary depending on the manufacturer and product batch, so patients should read the drug instructions carefully before taking the medication and consult a doctor or pharmacist when necessary to ensure the accuracy of the medication.

References:

https://www.drugs.com/dosage/brigatinib.html