Quizartinib instructions, indications, usage and dosage, side effects

Indications: Quizartinib is used with other chemotherapy drugs to treat a certain type of acute myeloid leukemia (AML; a cancer of white blood cells).

Usage and dosage: The treatment course includes three main stages: induction therapy, consolidation therapy and maintenance therapy. Patients can receive up to 2 cycles of induction therapy, combined with cytarabine and an anthracycline; followed by up to 4 cycles of consolidation therapy, combined with high-dose cytarabine; finally, patients can receive up to 36 cycles of quizartinib maintenance therapy, or until disease progression or unacceptable toxicity. Maintenance therapy should be started after consolidation chemotherapy and after the patient's blood cell count recovers to an absolute neutrophil count >500/mm3 and a platelet count >50,000/mm3.

In terms of dosage, specific recommendations are as follows:

Induction therapy dose:

For the "7+3" regimen, quizartinib is 35.4 mg orally administered once daily on days 8-21, along with cytarabine (days 1-7) and daunorubicin or idarubicin (days 1-3).

If you choose the second induction "5+2" regimen, quizartinib will be administered on days 6-19 or 8-21, depending on the schedule.

Consolidation therapy dose:

During the consolidation phase, quizartinib was administered orally once daily at 35.4 mg on days 6-19, combined with high-dose cytarabine (days 1, 3, and 5).

Maintenance therapy dose:

In the maintenance treatment phase, if the patientQTcF (corrected QT interval) ≤ 450ms, 26.5 mg of quizartinib will be taken orally daily on days 1-14, and then the dose will be increased to 53 mg once a day starting from day 15 of the first cycle.

If QTcF >500 ms is observed during induction or consolidation therapy, maintain the maintenance therapy dose at 26.5 mg once daily for up to 36 28-day cycles.

SIDE EFFECTS: Get emergency medical help if you have signs of an allergic reaction while using Quizartinib: hives, trouble breathing, swelling of the face, lips, tongue, or throat.

Quizartinib may cause serious heart problems, especially if you take certain medicines together. If you develop symptoms such as an irregular heartbeat, dizziness, feeling like you're going to pass out, diarrhea, or vomiting, contact your doctor right away. If you develop certain side effects, your dose may be reduced and your treatment may be delayed or permanently stopped.

Common side effects of Quizartinib may include: nausea, vomiting, stomach pain, upset stomach, diarrhea, loss of appetite; fungal infection; sepsis (a serious reaction to an infection); stinging eyes; nosebleeds; cold symptoms, such as stuffy nose, sneezing, sore throat; herpes infection; trouble sleeping; low platelets in the blood; electrolyte imbalances (such as low levels of potassium or magnesium in the blood); changes in liver function tests; abnormal electrocardiogram or ECG (sometimes called ECG) EKG); or low blood count - fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, dizziness, or shortness of breath. This is not a complete list of side effects and others may occur.

Precautions: Quizartinib may cause serious heart problems, especially if you take certain medicines together. If you develop symptoms such as an irregular heartbeat, dizziness, feeling like you're going to pass out, diarrhea, or vomiting, contact your doctor right away.

You should not use quizartinib before taking this medicine if you are allergic to it or if you have: very low magnesium levels; very low potassium levels; long QT syndrome; or a history of ventricular arrhythmias or torsades de pointes. Tell your doctor if you have or have ever had: heart problems; or low levels of potassium or magnesium in your blood.

Storage: Quizartinib should be stored at room temperature (20°C to 25°C, the allowed temperature fluctuation range is 15°C to 30°C), away from high and low temperatures, direct sunlight and humid environments, and the original packaging must be kept and well sealed. Store away from children and pets to ensure medication safety.

Reference materials:https://www.drugs.com/dosage/quizartinib.html