The main functions and indications of obeticholic acid tablets

Obeticholic acid (Obeticholic acid) is a key drug used mainly in the treatment of primary biliary cholangitis (PBC), especially in patients who do not respond well to ursodeoxycholic acid (UDCA). PBC is a chronic liver disease that usually causes hepatic bile duct damage and cholestasis, which further leads to the gradual deterioration of liver function and may even develop into cirrhosis. Therefore, developing a correct and effective treatment plan is crucial to improve patients' quality of life and delay disease progression.

As a drug that requires a prescription, obeticholic acid must be used under the guidance and supervision of a physician. The drug can be used alone or in combination with UDCA to enhance the therapeutic effect. Obeticholic acid provides a viable alternative for patients who have been treated with UDCA but have failed to respond. In addition, obeticholic acid also shows good therapeutic potential in patients with compensated cirrhosis but without portal hypertension.

Before starting obeticholic acid, doctors will carefully evaluate the patient's condition to ensure that the patient does not have decompensated cirrhosis or other serious liver complications, such as ascites or esophageal varices due to portal hypertension. These conditions may affect the safety and effectiveness of the drug and therefore require special attention.

The dosage of obeticholic acid varies among individuals. Normally, the recommended dose for adults in the initial stage of treatment is 5 mg per day. After three months of continuous use, the doctor may adjust the dose based on the patient's tolerance and efficacy, but the maximum dose shall not exceed 10 mg per day. The medication and dosage for pediatric patients need to be determined by the doctor based on the specific situation, which highlights the personalization and professionalism of the use of this drug.

Reference materials:https://www.mayoclinic.org/drugs-supplements/obeticholic-acid-oral-route/description/drg-20312281