Is colexitinib/sondido a hormonal drug?

Deucravacitinib is often mistaken by some patients for traditional hormonal drugs. This is because glucocorticoids have long played an important role in the treatment of plaque psoriasis, and many people subconsciously associate new drugs with hormones. In fact, deuterated colexitinib is not a hormone drug, but an innovative oral small molecule targeted drug whose mechanism is completely different from that of hormones. It is a selective tyrosine kinase 2 (TYK2) inhibitor. It mainly acts on the JAK-STAT signaling pathway to block the transmission of inflammatory factors related to psoriasis, thereby achieving the purpose of controlling the disease. Compared with hormone drugs, it does not directly suppress the overall function of the immune system, but is more targeted, reducing dependence, rebound or typical side effects caused by long-term use of hormones.

In actual treatment, patients will pay more attention to its safety. Common side effects of traditional hormone therapy include skin atrophy, weight gain, osteoporosis, etc. However, deuterated coxitinib does not show these typical hormone adverse reactions in clinical application, which is one of the reasons why it has attracted the attention of doctors and patients. Overseas literature points out that colexitinib is well tolerated and can provide patients with a smoother course of treatment, especially in the long-term management of psoriasis.

Therefore, when patients consult "Is deuterated coxitinib a hormonal drug?" they can clearly understand: it is a new type of targeted drug that is not a hormone and does not rely on hormonal mechanisms to control the condition. This is particularly important for psoriasis patients who require long-term medication, as it means they can avoid the burden of overuse of hormones while achieving long-lasting effects by precisely suppressing inflammatory signals. As it is approved for marketing in China in 2023, more and more patients are coming into contact with this drug. Correctly distinguishing drug categories can help eliminate concerns about hormone side effects and improve treatment compliance.

Reference materials:https://go.drugbank.com/drugs/DB16650