What is the difference between Midostaurin and Midocalin?

In clinical studies at home and abroad, we sometimes see the two names "midostaurin" and "midocalin", and many patients mistakenly think they are two different drugs. In fact, the English name of Midostaurin is called "Midocalin" in some literature and translations. The two are essentially the same drug, but there are differences in Chinese transliteration, trade name, and research stage name.

Midostaurin is a small molecule kinase inhibitor developed by Novartis. It was first discovered to have anti-leukemia potential when it was studied as an inhibitor of tyrosine kinases such as KIT and FLT3. Later, clinical trials confirmed that it has certain efficacy in FLT3 mutation-positive acute myeloid leukemia and systemic mastocytosis (SM), so it gradually entered clinical application. Midostaurin, as the original drug, has been approved in the European and American markets for many years, but it has not yet been fully commercialized in mainland China. Therefore, you will see the name "Midostaurin" in some materials to refer to the same molecule.

It needs to be particularly emphasized that midostaurin and midocalin are not two drugs with different structures or indications, but the difference is caused by different name translation or channels. When checking information or purchasing drugs, patients should use Midostaurin as its international common name to avoid misunderstandings or drug purchasing risks caused by name confusion. As domestic and foreign drug approval policies gradually accelerate, the standardized introduction of midostaurin and domestic generics in the future may solve the problem of drug accessibility and benefit more patients with FLT3 mutation-positive acute myeloid leukemia (AML).

Therefore, it can be understood that there is no substantial difference between midostaurin and midocalin. They are different names for the same drug. The key is to confirm whether it is a compliant drug from formal channels.

Reference materials:https://go.drugbank.com/drugs/DB06595