Is Aprecitentan (Tryvio) treatment expensive?

Aprocitentan-Tryvio is a new endothelin receptor antagonist mainly used to treat patients with refractory hypertension. Aprecitentan may be used as a complementary option for adult patients whose blood pressure cannot be effectively controlled despite a combination of conventional antihypertensive drugs. By blocking the endothelin pathway, the drug can significantly dilate blood vessels and reduce peripheral resistance, thereby effectively lowering blood pressure. Clinical studies have shown that in patients with such resistant hypertension, aprecitentan can further reduce the risk of cardiovascular and cerebrovascular complications, including stroke and myocardial infarction. Therefore, its indications are clearly positioned and mainly targeted at patient groups that cannot be adequately controlled by other drugs.

In terms of cost, aprexitentan has not yet been officially launched in mainland China. Therefore, if domestic patients need it, they usually need to rely on overseas drug purchase channels. According to overseas market information, the specifications of the original drug are 12.5 mg and 30 tablets, and each box is priced at about US$800. The price is relatively high in RMB and fluctuates significantly due to exchange rate changes. In comparison, the generic version of the drug that has been launched in Laos has the same specification of 12.5 mg and 30 tablets, and the price per box is about 600 yuan, which is relatively more affordable. This price difference provides an alternative for some patients who are under financial pressure.

Compared with other traditional antihypertensive drugs, the cost of aprecitentan is indeed higher, but considering that it targets high-risk groups, its clinical value lies not only in further lowering blood pressure, but also in reducing the incidence of cardiovascular events. In the long run, it can reduce the medical costs caused by hospitalization for stroke, myocardial infarction, and treatment of complications. Aprecitentan represents a new therapeutic hope for patients who cannot control their blood pressure with conventional medications.

Reference materials:https://go.drugbank.com/drugs/DB15059