Hidden dangers of long-term use of tenofovir alafenamide tablets (Vemlidy) once a day

Tenofovir alafenamide fumarate tablets (Vemlidy/Vemlidy) is an oral nucleotide reverse transcriptase inhibitor (NRTI), mainly used for antiviral treatment of patients with chronic hepatitis B virus (HBV) infection. By inhibiting the activity of HBVreverse transcriptase, the drug effectively reduces serum HBV DNA levels, improves liver function indicators, and shows a high resistance barrier in clinical practice. Its characteristics are that it is convenient to take one pill a day and can maintain viral suppression with long-term use.

Long-term use of tenofovir alafenamide fumarate tablets may have a certain impact on renal function. Although tenofovir alafenamide is less nephrotoxic than tenofovir disoproxil, a small number of patients develop elevated creatinine or tubular injury during long-term treatment. Especially elderly patients or people with underlying kidney diseases such as diabetes and hypertension need to regularly monitor serum creatinine and urinary protein indicators to detect potential renal function abnormalities as early as possible.

Long-term use of nucleotide antiviral drugs may also affect bone mineral metabolism, leading to a decrease in bone density. Although tenofovir alafenamide has low bone toxicity, long-term treatment may still increase the risk of osteoporosis in some patients. Clinically, it is recommended that patients undergo regular bone density testing, pay attention to supplementing calcium and vitamin DD, and maintain moderate exercise to reduce the risk of fractures.

In addition, long-term use of tenofovir alafenamide fumarate tablets may lead to lactic acidosis, abnormal liver function, or changes in body weight and lipid metabolism, especially in patients with other liver or metabolic diseases. In order to reduce the risk, patients should perform regular blood, liver and kidney function and bone density monitoring under the guidance of a doctor, and adjust the treatment plan or dose based on the test results. Generally speaking, long-term use of one pill per day is highly convenient, but the above potential risks still need to be paid attention to to achieve a balance between efficacy and safety.

Reference link:https://www.drugs.com